
Rational Design of Multifunctional Complex Molecular Architectures via Dynamic Covalent Chemistry
PhD Dissertation presentation exploring the systematic approach to creating complex materials through reversible chemical bonds.

Organic Synthesis | Materials Science | Product Development
My work begins at the molecular level. Rooted in organic synthesis, my research spans from the construction of dynamic polymer systems, macrocyclic architectures, and porous organic materials to the design of bioactive small molecules, including nor-pyochelin analogs engineered to disrupt iron metabolism in multidrug-resistant pathogens. I design and synthesize covalent organic frameworks (COFs) and functional materials through dynamic covalent chemistry and targeted post-synthetic modification. My research brings together organic synthesis, polymer chemistry, materials science, and data-driven strategies to engineer functional systems with applications in energy, health, and environmental remediation.
Synthesis and characterization are two sides of the same coin in my workflow. Structural and analytical data feed directly back into synthetic decisions, ensuring every molecule and material is not just made but understood. The applications I target demand performance under real-world conditions, and that focus drives the research.
My approach integrates structured process improvement principles that sharpen experimental reproducibility and accelerate discovery. Beyond the bench, I am actively building proficiency in artificial intelligence and machine learning, with growing interest in how these tools can be applied across scientific and real-world domains. At the University of Massachusetts Lowell, I conduct postdoctoral research at the intersection of chemistry, materials innovation, and applied impact, where molecular design meets real-world problems worth solving.
Postdoctoral Researcher, University of Massachusetts Lowell, (2025–Present)
Ph.D. (Organic Chemistry), University of Massachusetts Lowell, (2020–2025)
Dissertation: Rational Design of Multifunctional Complex Architectures via Dynamic Covalent Chemistry
Advisor: Prof. Olof Ramström
B.Sc. (Chemistry), University of Lagos, Nigeria (2014–2018, 4.90/5)
Thesis: Assessing a Triphasic Porous System for Phosphorus Removal from Laundry Effluent
Supervisors: Distinguished Prof. B. I. Alo & Dr. A. A. Abayomi

COFs are crystalline, porous polymeric networks constructed by linking organic building blocks with strong covalent bonds. I design COF materials with tailored pore structures and functionalities for applications such as gas storage, catalysis, and sensing.

In my MODEM project, I used a monofunctional modulator to direct the formation of imine-linked 2D COFs with enhanced crystallinity and porosity. I optimized parameters to suppress rapid nucleation and promote long-range order.

I exploit reversible organic reactions to build adaptive polymer networks. Recent projects include the synthesis of organogels that are self-healable, regenerable, and degradable, and the investigation of unprecedented macrocyclization pathways in dynamic systems.

I adapt Lean Six Sigma principles in scientific research using DMAIC and DMADV frameworks to streamline experiments and advance material development. Lean eliminates inefficiencies, while Six Sigma boosts precision and reproducibility. Together, they foster a structured workflow that elevates my research quality.
University of Massachusetts Lowell
2025
University of Massachusetts Lowell
2022 - 2024
National Organization for the Professional Advancement of Black Chemists and Chemical Engineers
2024 & 2025
DuPont
2024
University of Lagos
2018
Best Graduating Student in Organic Chemistry
Continuous professional development in process optimization, quality management, and specialized technical skills.
Council of Six Sigma Certification
2024
Foundation in Six Sigma methodology and quality management principles
Council of Six Sigma Certification
2024
Advanced understanding of DMAIC framework and process improvement
Biopharma Group (UK)
2025
3-Day intensive workshop covering product characterization, cycle development, scale-up, and advanced freeze-drying techniques
Ayinla, M.; Zhao, R.; Azzarito.; Qi, Y.; Che, F.; Ramström, O.
ChemRxiv, 2026
PreprintAyinla, M.
Proquest, 2025
DissertationQi, Y.; Ayinla, M.; Yang, Z.; Ramström, O.
Chem. Eur. J. 2025, 31, e202404720
PublishedQi, Y.; Ayinla, M.; Clifford, S.; Ramström, O.
J. Org. Chem. 2024, 89 (2), 1091–1098
PublishedRaviranga, N. G. H.; Ayinla, M.; Perera, H. A.; Qi, Y.; Yan, M.; Ramström, O.
ACS Infect. Dis. 2024, 10 (11), 3842–3852
PublishedKaralius, A.; Qi, Y.; Ayinla, M.; Szabo, Z.; Ramström, O.
Chem. Eur. J. 2024, 30, e202402409
PublishedQi, Y.; Ayinla, M.; Sobkowicz, M. J.; Ramström, O.
Macromol. Rapid Commun. 2023, 44, 2300011
PublishedNigerian Society of Chemical Engineers (NSChE) Rivers/Bayelsa Chapter Technical Meeting
Virtual
DuPont GOLD Seminar at DuPont Experimental Station
Wilmington, DE
NOBCChE Conference
Atlanta, GA
NOBCChE Conference
Orlando, FL
ACS Fall National Meeting
San Francisco, CA
Organic Chemistry Seminar
Lowell, MA
I am committed to mentoring and community service, guiding emerging scientists through research, leadership, and academic engagement.
Supervised undergraduate students in the synthesis and characterization of reticulated materials, emphasizing experimental design, analytical techniques, and sustainable materials development.
Mentored graduate students pursuing green and scalable synthesis of COFs, data-driven materials optimization, and dynamic covalent chemistry for environmental and energy applications.
Represented the graduate student community; Supported initiatives that promoted professional development, academic involvement, and student advocacy.
Launched the university's inaugural competition in collaboration with the Graduate School.
Evaluated candidates for the university's highest teaching recognition.
Reviewed research submissions for ACS Omega, Wiley ChemMedChem, ACS Industrial & Engineering Chemistry Research, Sigma Xi International Forum on Research Excellence (IFoRE), IEEE-MIT Undergraduate Research Technology Conference (URTC), Virginia Junior Academy of Science (VJAS), California Science & Engineering Fair (CSEF).
Insights into covalent organic frameworks, dynamic chemistry, Lean Six Sigma methodology, and the intersection of materials science with process optimization.

PhD Dissertation presentation exploring the systematic approach to creating complex materials through reversible chemical bonds.

Explored synthesis of novel, crystalline COFs using aniline as a monofunctional modulator to enhance structure.

Explaining self-healing and adaptive polymers enabled by reversible chemistry and their applications in sustainable materials.

Discussing how Lean waste-elimination and Six Sigma quality control can improve lab processes and accelerate discovery.

A reflection on resilience, community, and the power of shaping spaces beyond limits, delivered to the Class of 2025.

Exploring how green chemistry principles and process optimization can drive innovation in materials science.
Interested in collaboration, research opportunities, or have questions about my work? I'd love to hear from you.